Synthetic tools for studying the chemical biology of InsP8 † †Electronic supplementary information (ESI) available: Data deposition: atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID codes 5BYA and 5BYB). See DOI: 10.1039/c5cc05017k

نویسندگان

  • Andrew M. Riley
  • Huanchen Wang
  • Stephen B. Shears
  • Barry V. L. Potter
چکیده

a Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK. b Inositol Signaling Group, Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA. c Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase† †Electronic supplementary information (ESI) available: Data deposition: the atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID code 4GB4). See DOI: 10.1039/c2cc36044f Click here for additional data file.

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

متن کامل

Engineering proximal vs. distal heme–NO coordination via dinitrosyl dynamics: implications for NO sensor design† †Electronic supplementary information (ESI) available: Structure factors and atomic coordinates have been deposited in the RCSB Protein Data Bank with accession codes; 5JT4, 5JLI, 5JP7, 5JRA, 5JVE, 5JUA, 5JSL, 5JS5. See DOI: 10.1039/c6sc04190f Click here for additional data file.

School of Biological Sciences, University of CO4 3SQ, UK. E-mail: [email protected] Department of Chemistry and Biochemistry Oregon 97850, USA. E-mail: candrew@eou. Faculty of Science and Education Science, Iraq Medical Research Center, Hawler Medical Swiss Light Source, Paul Scherrer Institute, Manchester Institute of Biotechnology, 131 School of Chemistry, Bangor University, Ba Molecular Bio...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 51  شماره 

صفحات  -

تاریخ انتشار 2015